T1.2
Mitral valve prolapse/ Mitral annular disjunction
Mitral valve prolapse (MVP) is a relatively frequent valve disorder, affecting 2-4% of the general population. In most cases, the prognosis for individuals with this condition is good. However, a subset of patients with MVP are at risk of sudden cardiac death. The specific mechanisms underlying the development of arrhythmias in these individuals remain largely unknown. Mitral annular disjunction (MAD) is one of the arrhythmogenic risk factors. The genetic background of both MVP and MAD is still largely unknown and efficient therapeutic strategies are missing.
Credit: Lars Dejgaard and Kristina Haugaa, Hjerteforum 2019.
The objectives of ProCardio’s research are to uncover the etiology and mechanisms of arrhythmias in patients with MVP, including using simulation models, in order to identify potential therapeutic targets, as well as developing automatic MVP/MAD detection software.
Projects
- Flecainide in arrhythmic mitral valve prolapse (FLECAPRO)
- Ventricular arrhythmias in patients with arrhythmic mitral valve prolapse
- Prediction of arrhythmic risk in patients with mitral annular disjunction
- Risk stratification of patients with mitral valve prolapse by precision medicine
- Simula: Arrhythmic mitral valve prolapse
Publications
- Lifetime exercise dose and ventricular arrhythmias in patients with mitral valve prolapse
- Prediction of severe ventricular arrhythmias in patients with mitral valve prolapse by exercise ECG (Link to publication)
- Revisiting the link between keratoconus and mitral valve prolapse (Link to publication)
- Mitral valve prolapse: arrhythmic risk during pregnancy and postpartum (Link to publication)
- Flecainide in patients with arrhythmic mitral valve syndrome: A case series (Link to publication)
- Mitral Annular Disjunction: Normal or Abnormal: It Is All About Location (Link to publication)
- Ventricular arrhythmias in arrhythmic mitral valve syndrome-a prospective continuous long-term cardiac monitoring study (Link to publication)
- Electrical markers and arrhythmic risk associated with myocardial fibrosis in mitral valve prolapse (Link to publication)
- Mitral Annulus Disjunction: Arrhythmic But Not Deadly? (Link to publication)
- Cardiac arrest, mitral annular disjunction, and mitral valve prolapse: where there is smoke, there is a fire (Link to publication)
- Cardiac Arrest in a Patient With Arrhythmic Mitral Valve Prolapse Syndrome: Multiple Possible Etiologies (Link to publication)
- Tricuspid Annulus Disjunction: Novel Findings by Cardiac Magnetic Resonance in Patients With Mitral Annulus Disjunction (Link to publication)
- Stretch of the papillary insertion triggers reentrant arrhythmia: an in silico patient study (Link to publication)
